Cascarilla is often used in rituals for protection, purification, and spiritual cleansing. Practitioners may use it to draw symbols or patterns on surfaces, sprinkle it around spaces, or even apply it directly to the skin as a form of protection. The substance is believed to have purifying and protective properties, warding off negative energy and entities.

In addition to its spiritual uses, cascarilla has also been utilized in traditional medicine for its purported healing properties, such as treating skin irritations and digestive issues.

This may be added to spiritual baths, placed on the third eye for protection and grounding, placed at the bottom of the feet for grounding and used in spiritual ceremonies.